β3-AR agonist 2 

β₃-AR agonist 2 is a potent and selective β₃-adrenergic receptor (β₃-AR) agonist with an EC₅₀ of 8 nM.

EC50: 8 nM (β₃-adrenergic receptor)^[1]

β₃-AR agonist 2 (Compound 26e) is found to be potent and selective at the β₃ receptor, nearly completely abolishes intrinsic activity at either the β₁ or β₂ receptor^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

β₃-AR agonist 2 (Compound 26e) has significant thermogenesis effects on human β₃-adrenergic receptor transgenic mice. β₃-AR agonist 2 acts as a potential drug for the treatment of human obesity and type II diabetes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

562.68

C₂₇H₃₈N₄O₇S

340757-05-3

CC(C)C[C@@H](C(O)=O)NC(C1=CC=C(N2CCC(NC[C@H](O)C3=CC=C(O)C(NS(=O)(C)=O)=C3)CC2)C=C1)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Hu B, et al. (4-Piperidin-1-yl)phenyl amides: potent and selective human beta(3) agonists. J Med Chem. 2001 Apr 26;44(9):1456-66.  [Content Brief]